2020-21
| Date | Opponent | Result | Record | Preview |
| Thu, 11/26 | vs. No. 1 Gonzaga (Ft. Myers, FL) | L, 90-102 | 0-1 | Link |
| Fri, 11/27 | vs. Saint Joseph’s (Ft. Myers, FL) | W, 94-72 | 1-1 | Link |
| Tue, 12/1 | vs. No. 10 Kentucky (Champions Classic) | W, 65-62 | 2-1 | Link |
| Thu, 12/3 | WASHBURN | W, 89-54 | 3-1 | Link |
| Sat, 12/5 | NORTH DAKOTA STATE | W, 65-61 | 4-1 | Link |
| Tue, 12/8 | No. 8 CREIGHTON | W, 73-72 | 5-1 | Link |
| Fri, 12/11 | OMAHA | W, 95-50 | 6-1 | Link |
| Thu, 12/17 | at No. 14 Texas Tech | W, 58-57 | 7-1 (1-0) | Link |
| Tue, 12/22 | No. 7 WEST VIRGINIA | W, 79-65 | 8-1 (2-0) | Link |
| Sat, 1/2 | No. 8 TEXAS | L, 59-84 | 8-2 (2-1) | Link |
| Tue, 1/5 | at TCU | W, 93-64 | 9-2 (3-1) | Link |
| Sat, 1/9 | OKLAHOMA | W, 63-59 | 10-2 (4-1) | Link |
| Tue, 1/12 | at Oklahoma State | L, 70-75 | 10-3 (4-2) | Link |
| Mon, 1/18 | at No. 2 Baylor | L, 69-77 | 10-4 (4-3) | Link |
| Sat, 1/23 | at Oklahoma | L, 68-75 | 10-5 (4-4) | Link |
| Thu, 1/28 | TCU | W, 59-51 | 11-5 (5-4) | Link |
| Sat, 1/30 | at No. 18 Tennessee | L, 61-80 | 11-6 | Link |
| Tue, 2/2 | KANSAS STATE | W, 74-51 | 12-6 (6-4) | Link |
| Sat, 2/6 | at No. 17 West Virginia | L, 79-91 | 12-7 (6-5) | Link |
| Mon, 2/8 | No. 23 OKLAHOMA STATE | W, 88-76 | 13-7 (7-5) | Link |
| Thu, 2/11 | IOWA STATE | W, 97-64 | 14-7 (8-5) | Link |
| Sat, 2/13 | at Iowa State | W, 64-50 | 15-7 (9-5) | Link |
| Wed, 2/17 | at Kansas State | W, 59-41 | 16-7 (10-5) | Link |
| Sat, 2/20 | No. 15 TEXAS TECH | W, 67-61 | 17-7 (11-5) | Link |
| Tue, 2/23 | at No. 14 Texas | L, 72-75 (OT) | 17-8 (11-6) | Link |
| Sat, 2/27 | No. 2 BAYLOR | W, 71-58 | 18-8 (12-6) | Link |
| Thu, 3/4 | UTEP | W, 67-62 | 19-8 | Link |
| Thu, 3/11 | vs. (7) Oklahoma (Big 12 Quarters) | W, 69-62 | 20-8 | Link |
| Fri, 3/12 | vs. (3) Texas (Big 12 Semis) | CANCELLED | – | Link |
| Sat, 3/20 | vs. (14) Eastern Washington (Round of 64) | W, 93-84 | 21-8 | Link |
| Mon, 3/22 | vs. (6) USC (Round of 32) | 8:40 pm CDT | – | Link |
